Table of Contents
| Articles/ Presentations/Classes | PK-PD | Analgesics | Anticancer | Benzodiazepines | Molecular Modeling | C&EN Articles |
-
Acid-Base
Equilibria and Buffers lecture notes, graphics, examples, sample problems, etc. from
a biochem lecture. -
Acid-Base
Study Questions not too long,
but you'll find it interesting, and may even learn something!
- Adrenergic Pharmacology Tutorial adrenergic SAR - uses Chime - nice.
- Adult Neurogenesis in Mammals a short review article on an adult's ability to grow new nerve cells - something thought impossible until very recently.
- Biological Membranes part of U. Kansas' on-line book, Medical Biochemistry
- Concepts in Biochemistry by Jim Hardy at U. Akron, who has authored a number of great tutorials and on-line books
- Drugs, Brains and Behavio a full-length electronic textbook by C. R. Timmons & L.W. Hamilton.
- Drug Design from the Molecular Design Laboratory in China.
-
Drug-Receptor
Interactions a very readable chapter on the
forces between receptors and xenobiotics.
- Interactive Patient, The very slick interactive diagnostic drill - quite realistic, with both visual and audio feedback.
- Introduction to Bacteria straightforward, nine-page background item.
- Introduction to PCR complete with a neat simulation of how this valuable technique works to increase DNA quantities.
- Medical Pharmacology and Disease-Based Integrated Instruction - basic pharmacol. course for medical students.
- Neurogenesis in Adult Mammals: Some Progress and Problems a followup piece to the fourth article down in this list.
- Physicochemical Principles of Drug Action nice PowerPoint presentation that hits all the essentials.
- Principles of Drug Action functional groups, acid-base chemistry and physicochemical properties. Includes study questions.
- Protein G Structure Tutorial how to set up protein structures using Chime.
- Signal Transduction part of U. Kansas' on-line book, Medical Biochemistry
- Structure-Based Drug Design Review great J. Med. Chem. perspective on application of the 3D structures of protein target molecules in structure-based drug design.
- Theory of Drug Design a concise overview of the drug discovery and development process. Several examples, developed via their approach, are also presented. There are many other, quite sophisticated, pages on this site.
- Theory and Practice of Receptor Characterization and Drug Analysis actually a full, multiweek course.
Pharmacokinetics-Pharmacodynamics Cytochrome
c Oxidase - the "Molecule of the Month"
entry from PBD's series. Short tutorial on this oxidation
catalyzing enzyme.- Dosage Forms from the FDA, a compilation of every drug formulation you've ever heard of, and lots that you haven't.
- A First Course in Pharmacokinetics and Biopharmaceutics from the Univ. of Oklahoma College of Pharmacy.
- How the Kidney Works animated guide to kidney function - more sophisticated than it first appears.
- Principles of Drug Action and Therapeutics II brain chemistry, neurotransmitters, neurology
- Principles of Drug Action and Therapeutics III analgesics (opiates), local anesthetics, mental illness
- Pharmacokinetics an extremely nice summary of drug distribution, metabolism, receptor
interaction - the big picture!
- Pharmacokinetics
and Biopharmaceutics great course homepage from U. of IA,
featuring excellent tutorials, lecture notes in either ppt or pdf
format, sample questions, competencies, etc.
- Pharmacokinetics - Biopharmaceutics pharmaceutical analysis, molecular modeling, structure optimization. Some particularly good, fairly short chapters include the following:
- Routes
of Drug Administration describes each route, with the
pluses/minuses for each.
- Pharmacokinetics
of Oral Administration an introduction to the kinetics of oral
drug delivery.
- Physical-Chemical
Factors Affecting Oral Absorption discusses many factors,
including the pH-partition hypothesis.
- Physiological
Factors Affecting Oral Absorption membrane permeability, GI
physiology (incl. pH).
- Distribution - discusses the "big picture" of drug distribution, esp. protein
binding.
- Metabolism
esp. renal, and its effect
on other body functions.
- Pharmacy - the WWW Virtual Library typical super collection of links from the Virtual Library - pharmaceutical schools, companies, databases, gov't. sites, conferences, etc.
- Routes
of Administration very nice summary, by Cornell's Vet. Med.
School.
- Your
Kidneys and How They Work NIH's
guide aimed at high school students...think it'll be beneath you? (It
won't.)
Background
Reading on Major
Drug Classes
Analgesics
PowerPoint slideshows
- Adjuvant Analgesics (32 slides) from Beth-Israel in New York - analgesics used in combination with others
- Analgesics: Drug Discovery (46 slides from Astra-Zeneca really excellent overview of NSAIDS, corticosteroids, and opiates, along with the mechanism of pain transmission
- The Major Opioids (52 slides) just what it says! Nice summary, covering everything from pharmacology to business aspects.
- Opioid Analgesics (38 great slides from Beth-Israel) - really well done
- Opioids in Chronic Pain (36 slides from Beth-Israel) something near and dear to my foot....I mean, heart. ;-) A great slide show from one of the nation's experts on chronic pain and RSD
- Etiology and Pathophysiology of Pain (32 slides from Beth-Israel) nice explanation of the origin and transmission of pain signals - quite detailed, but not difficult to follow
- Pathophysiology of Pain (22 slides from Beth-Israel) concentrates on the physical reasons for and Tx of pain
- Pharmacotherapy of Pain (63 slides from Beth-Israel) very complete outline of the Tx of pain
The Addict and the Law - essentially an early version of "Addiction and Opiates", this gives a fascinating look at the early days of drug prohibition and criminalization of drug addiction.
Addiction and Opiates - a critical review of the field by Alfred Lindesmith, one of the early authorities.
Consumers Union Report on Licit and Illicit Drugs- although somewhat dated (1972), it's still an excellent resource.
Definition of terms and classification of dependence-producing drugs
Discovery of Novel Opioid Medications a multi-chapter NIDA report - 318pp!
Molecular Approaches to Drug Abuse Research recommended chapters are marked in the table of contents
Neurological Processes of Pain one of the Talaria collection of tutorials, from the Pain Research Center at the Univ. of Utah - narrated, and it's actually not irritating! Rather, it's the best example of narrated tutorials, and what they can accomplish, that I have ever encountered - CHECK THIS OUT!!
Opioid Receptors1 a good technical paper, surprisingly easy to read and follow
Opioids: Glossary1 not just opioid-related terms, but lots of pharmacological terms as well
Pharmacokinetics of the Opioids combination outline/notes; primarily concerned with opioid use in terminal cancer
Use of Opioid Analgesics for the Treatment of Chronic Non-Cancer Pain a consensus report from the Canadian Pain Society, published in their journal, Pain Research & Management
AntiCancer Drugs
There are a multitude of sites with specific information about anticancer drugs, mechanisms of action, etc. However, a great set of pages that encapsulates the data nicely is from Purdue's College of Vet. Medicine. Hey, if the network is actually working, you'll be able to see the links from these pages to Purdue!
Chemotherapy part of the Medical Pharmacology course
Pharmacology of Cancer Therapy lengthy; essentially a set of lecture notes - very complete, outline form
Chemotherapy of Neoplastic Diseases similar to above, except for more hard data are included
Table from above outlines typical doses, routes, and precautions - very
interesting, for the clinician
Table
from above covers drug
preparations and storage - not as interesting as the above table, but
worth a look Chemotherapy - Drug Groups
short tabulation - great overview
Benzodiazepines and Other Minor Tranquilizers
The Benzodiazepine Story the whole story from one of the discoverers at Hoffmann-La Roche - great!
Benzodiazepines (Systemic) from MedLinePlus, sponsored by NLM of the NIH - great, complete summary
Benzodiazepines for Anxiety from a pamphlet from a U.K. health site
Stopping Long-Term Benzodiazepines the joys of withdrawing from a very addictive class of drugs
About Benzodiazepines from an Australian site about the dangers of long-term benzo therapy
- 3D Pharmaceutical Structure Database library of all Japanese Rx products, along with modeling software and tutorials.
- Advanced Biomedical Computing Center home of Sybyl, the comprehensive software package.
- C4
Molecular Library great way to get comfortable with Chime and to
learn how to manipulate the >400 structures.
- CAChe Computer Aided
Chemistry a well organized
introduction to molecular modeling and how it is usp-ed.
- Chime and Mozilla Chime does not automatically install into browsers other than NS and IE, so here's how to use it with Mozilla.
- Chime vs. Rasmol although Chime is the modern and newer reincarnation of Rasmol.
- Computers
in Drug Design - Part 1 involves
examining and appreciating the 3D aspects of the four potential
anti-HIV agents with Chime; this outlines
scripting with Chime, enabling the automated illustration of tutorials,
primers, etc. Part
2, on the other hand, enables you to manipulate the drug as it's
bonded to the receptor. Chime scripting allows it to run as a
tutorial, where you click the buttons you're asked to; it a very
effective way to visualize this complex interaction.
- Introduction to Macromolecular Simulation a lengthy, mathematically rigorous tutorial on classical vs. quantum mechanics.
- Introduction to Molecular Modelling and Computer Simulation very good introduction to the whole idea, plus loads of excellent links at the end of each section.
- An Introduction to QSAR Methodology great starting point for QSAR novices - uses capsiacin as a model substrate.
- Membrane Channel and Pump Structures a Chime site covering the representation of channels. ion pumps, etc.; uses .
- Molecular Modeling for Organic Chemistry an eight lecture/demo course by Dr. Henry Rzepa (Imperial).
- Molecular Models over 1400 cmpds. in pdb
format, subdivided into categories like fnc. grp., type of application
(drug, etc.).
- Molecule Viewing Scripting Wizards an ingenious collection of JS-powered aids to help write Chime and similar scripts.
- NSF, Science Magazine Honor Striking Visuals worth a look! Some of the most amazing images you'll see in awhile.
- The Online
Macromolecular Museum beautifully done display of
macromolecules from enzymes to proteins.
- ORTEP-III Oak Ridge Thermal Ellipsoid Plot Program for Crystal Structure Illustrations.
- Protein-Ligand Docking Using AutoDock 3.05 developed by Prof. Arthur Olson at Scripps, this software is used for modeling flexible small molecule such as drug molecule binding to receptor proteins.
- Quantitative Structure Activity Relationships designed to quantify the small differences between close analogs to give a more accurate picture of the receptor, and hopefully to predict which derivative(s) are likely to be most active.
- Rasmol Version 2.6-b-2 Reference Manual the best documentation of RasMol, the program largely replaced by Chime.
- The QSAR and Modeling Society an international organization supporting QSAR and computational bioinformatics.
- The QSAR Server capable of online analysis using various methods and datasets.
- Sybyl/Base from Tripos® - " A Single Gateway to
Molecular Design and Analysis.
Current Items in Medicinal Chemistry from C&EN- Biotech Vies for Position With the drug industry pressed to find new paths to innovation, the tension between large- and small-molecule therapeutics takes center stage.
- Breaching Barriers Protein transduction and similar methods are promising techniques for delivering a wide variety of drugs directly into cells.
- Chiral Roundup As pharmaceutical companies face bleak prospects, their suppliers diligently tend the fertile fields of chiral chemistry in varied ways.
- Custom Synthesis for Drug Discovery Companies
provide exclusive synthesis for early drug development, keeping costs
down until drug viability is assured.
Drug Development Process chemistry results
in pharmaceutical manufacturing routes that are safe, efficient, and
scalable.- Drug Discovery Pure science yields to applied science as the genomics revolution focuses its energy on commercialization.
- Fighting the Clock Pharmaceutical and biotechnology companies seek ways to reduce the time required to discover and develop medicines.
- Fine Chemicals A survey of fine chemical manufacturers and their tactics for dealing with a weak economy (other than working against Jr.'s re-election).
- Generic Tide Is Rising Expiring patent protections and pressures on makers of brand-name drugs bode well for the generic pharmaceutical industry.
- Generics Next Wave With major biotech drugs coming off patent, generic drug makers are looking to compete.
- Green Chemistry for Pharma Symposium highlights how chemists apply green chemistry principles to pharmaceutical problems.
- Maximizing Returns A driving force in getting Taxol to market quickly, NIH is being asked to evaluate the way it deals with the private-sector partnerships. A great story about the development and marketing of Taxol®.
- Pharmaceuticals, Supplied Virtually Beta-Chem offers development capabilities despite owning neither plant nor lab.
- Synthetic Receptors Pull Molecules Into Cells custom targeting of synthetic receptors.
1. Both of these links are from the website opioids.com, which is a subdirectory of biopsychiatry.com; this site advocates and espouses a future utopian society, wherein everyone has a selection of psychoactive drugs to keep them in an "ecstatic" space, 24/7 (clearly, the site authors have been reading Aldous Huxley's "Brave New World"). Despite the site's rather unconventional premise, they are a source of a great many literature citations concerning just about any drug you could name. I cannot support its main premise, but the site can be both educational and fun to peruse. Where else could you find a homepage having the subtitle "The Responsible Parent's Guide to Healthy Mood-Boosters for All the Family"?
Got any links to add? Just drop me an e-mail with the link, and if it fits, it'll be in! Thanks!!
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