Recent Medical Literature (2011-2014)

NOTE: For summaries/citations of very recent research papers, check out, also, these pages in the RSDSA site: Clinical Guidelines. All articles in this page were published since 2010.

If you'd like a monthly summary of CRPS/RSD research and findings, please let me know!

Papers were published during the past two years, according to the following markers: Cyan marker (): 2011; Orange marker (): 2012; Red marker (): 2013. You'll see that a few pre-2010 publications are included, just because they're so very important.

Clicking an article's title will provide a PDF file of the paper.


A Clinical Guide to Opioid Analgesia technical, highly professional, 135-page handbook for any users/prescribers of opioids.

Complex Regional Pain Syndrome - What's in a Name? fascinating, 11-page paper that traces the evolution of names for CRPS, including what effect(s) inaccurate names might have on treat protocols and research.

Cutaneous Limb Inflammation Produces Analgesia... careful, well documented study showing the analgsic effect of capsiacin (pepper extract) and urging more detailed research on this promising technique.

Elevated Blood Levels of Inflammatory Monocytes (CD14+CD16+) in CRPS a detailed, sophisticated study examining the role of inflammation on the pathophysiology of CRPS

Erasure of a Spinal Memory Trace of Pain a fascinating description of experiments indicating that a single, high dose of an opioid agonist can stop the constant recycling of pain information that leads to chronic pain.

Feb. 2012 – Pain Product Announcements & Warnings "Fentanyl sublingual spray (Subsys®) approved for breakthrough cancer pain; FDA safety alert regarding Endo/Novartis opioid product packaging problem; natalizumab (Tysabri®) FDA safety alert; FDA approval of TIRF REMS program."

From Basic Science to Blockbuster Drug: The Discovery of Lyrica really wonderful article from the discoverer of Lyrica, Prof. Richard Silverman at Northwestern University (who also taught me more medicinal chemistry than any other faculty there).

Intravenous Regional Ketorolac and Lidocaine in CRPS Treatment these blocks were found to provide only short-term pain relief, except in juveniles, who are treated more successfully.

Jan 2012 – Pain Product Announcements & Warnings The excellent monthly summary from pain-topics.org is out early this month. Check out prior issues, see the menu item "Pain Product News & Warnings!" on the main site.

Ketamine-Induced Relief of Chronic Pain Dutch researchers showed that (S)-ketamine can give pain relief lasting "much longer than the treatment session". I'd hope so!

Lack of Efficacy of Intrathecal Baclofen in CRPS researchers concluded that intrathecal baclofen doesn't help with dystonia or pain, but may be a useful adjunct for those in whom opiates have become less effective.

Pain and other CRPS Symptoms Are Increased by Ambiguous Visual Stimuli an initial exploratory study probing the visual disturbances reported by the majority of CRPS patients

Passive Transfer of Immunoglobin G Serum Antibodies from Patients with Chronic CRPS showed that IgG from chronic CRPS patients can induce many CRPS symptoms in mice

Proposing a Scoring System for the Research Criteria of CRPS using the Budapest criteria, these researchers suggest a weighted structure for using the objective symptoms of CRPS to standarize Dx and thus hopefully Tx of CRPS

Role of the Sympathetic Nervous System in Osteoporotic Disease new insights into possible treatments for osteoporosis secondary to diseases involving the sympathtic nervous system, like CRPS.

Syncope in CRPS syncope or presyncope ("syncope" means a brief loss of consciousness due to transient lack of oxygen) is common in CRPS patients, esp. those with lower-extremity illness