Definitive Library for RSD/CRPS, Chronic Pain, and Similar Conditions
The RSD/CRPS Library
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Title of Article, Paper, Book, etc. (& link to PDF)
Citation
Methadone Metabolism
    Depending on genetic factors, people can metabolize methadone either unusually slowly or extremely rapidly. These factors can be very relevant in, for instance, drug monitoring programs using urinalysis to verify the presence of prescribed drugs. Some of these papers are quite heavy; in this case, let the titles be your guide.
β-Arrestin2 influences the response to methadone in opioid-dependent patients Pharmacogen. 2011, 11, 258
Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): Application to the chiral metabolism of mephenytoin and methadone Electrophoresis 2003, 24, 2577
Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism J. Pharm. Exptl. Ther. 2007, 321, 389
Enantiomers of Naringenin as Pleiotropic, Stereoselective Inhibitors of Cytochrome P450 Isoforms Chirality 2011, 23, 891
Enantioselectivity of Inhibition of Cytochrome P450 3A4 (CYP3A4) by Ketoconazole: Testosterone and Methadone as Substrates Chirality 2004, 16, 79
Glucocorticoid inhibition of vascular abnormalities in a tibia fracture rat model of complex regional pain syndrome type I Movement Disord. 2008, 23, 581
Interindividual Variability of the Clinical Pharmacokinetics of Methadone Clin. Pharmacokin. 2002, 41, 1153
Methadone-Drug Interactions; includes good section on metabolism (33 pp) Pain Treatment Topics 2006
Methadone Mortality – A Reassessment SAMHSA, 2007
Opioid Therapies and Cytochrome P450 Interactions J. Pain Symp. Mgmt. 2012, 44, S4
Pharmacogenomic study of opioid addicts in methadone treatment ( a 215pg thesis!) Opioid Addicts Meth. Treat. , PhD Thesis
Role of CYP2B6 in Stereoselective Human Methadone Metabolism Anesthesiology 2008, 108, 363
Stereoselective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation Basic Clin. Pharmacol. Toxicol. 2010, 108, 55
Stereoselective Metabolism of Methadone N-Demethylation by Cytochrome P4502B6 and 2C19 Chirality 2004, 16, 36
Suspected Opioid Overdose Case Resolved by CYP2D6 Genotyping Drug Monitor. 2012, 34, 121
Physical Therapy/PEPT
A Day-hospital Approach to Treatment of Pediatric Complex Regional Pain Syndrome Clin. J. Pain 2012, 28, 766
Comparison and critical evaluation of rehabilitation and home-based exercises for treating shoulder stiffness: Prospective, multicenter study with 148 cases Orthoped. Trauma Surg. Res. 2011, 97, S182
Chronic Regional Pain Syndrome: What Specialized Rehabilitation Services Do Patients Require? Curr. Pain Headache Rep. 2012, 16, 139
Complex Regional Pain Syndrome and Chiropractic J. Manip. Physiol. Ther. 2000, 23, 490
Does evidence support physiotherapy management of adult Complex Regional Pain Syndrome Type One? A systematic review Eur. J. Pain 2009, 13, 339
The effectiveness and cost evaluation of pain exposure physical therapy and conventional therapy in patients with complex regional pain syndrome type 1. Rationale and design of a randomized controlled trial BMC Musculoskeletal Disord. 2012, 13, 58
Is Physiotherapy Effective for Children With Complex Regional Pain Syndrome Type 1? Clin. J. Pain 2012, 28, 81
Physiotherapy management of complex regional pain syndrome N.Z.J. Physiother. 2013, 41, 65
A machine learning approach to assessing gait patterns for Complex Regional Pain Syndrome Med. Eng. Phys. 2012, 34, 740
More Than Meets the Eye: Clinical Reflection and Evidence-Based Practice in an Unusual Case of Adolescent Chronic Ankle Sprain Phys. Ther. 2011, 91, 1395
Treatment of Complex Regional Pain Syndrome - Functional Restoration Clin. J. Pain 2006, 22, 420
Ultrasound Appearance of Forearm Muscles in 18 Patients With Complex Regional Pain Syndrome 1 of the Upper Extremity Pain Pract. 2013, 1, 76
Pain Exposure Physical Therapy - these articles are in chronological order, so one can appreciate the refinement and greater proof of the concept over the relatively short time this technique has been used.
Reduction of pain-related fear in complex regional pain syndrome type I: The application of graded exposure in vivo Pain 2005, 116, 264
Pain exposure physical therapy may be a safe and effective treatment for longstanding complex regional pain syndrome type 1: a case series Clin. Rehabil. 2009, 23, 1059
Safety of ‘‘pain exposure’’ physical therapy in patients with complex regional pain syndrome type 1 Pain 2011, 152, 1431
The effectiveness and cost evaluation of pain exposure physical therapy and conventional therapy in patients with complex regional pain syndrome type 1. Rationale and design of a randomized controlled trial BMC-Musc. Skel. Dis. 2012, 13, 58
Reduction of pain-related fear and increased function and participation in work-related upper extremity pain (WRUEP): Effects of exposure in vivo Pain 2012, 153, 2109
Hyperbaric Oxygen Therapy (HBOT)
The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats Int. J. Mol. Sci. 2012, 13, 12224
Effectiveness of Hyperbaric Oxygen Therapy in the Treatment of Complex Regional Pain Syndrome J. Internat. Med. Res. 2004, 32, 258
Hyperbaric Oxygen in the Treatment of Patients With Cerebral Stroke, Brain Trauma, and Neurologic Disease Adv. Ther. 2005, 22, 659
Hyperbaric oxygen treatment decreases pain in two nerve injury models Neurosci. Res. 2010, 66, 279
Hyperbaric Oxygen Treatment Induces a 2-Phase Antinociceptive Response of Unusually Long Duration in Mice J. Pain 2010, 11, 847
Hyperbaric Oxygenation Therapy Alleviates Chronic Constrictive Injury–Induced Neuropathic Pain and Reduces Tumor Necrosis Factor-Alpha Production Anesth. Analg. 2011, 113, 626
Intractable livedoid vasculopathy successfully treated with hyperbaric oxygen Brit. J. Dermatol. 2003, 149, 647
A Prolonged Nitric Oxide-Dependent, Opioid-Mediated Antinociceptive Effect of Hyperbaric Oxygen in Mice J. Pain 2009, 10, 167
Safety and Efficacy of Hyperbaric Oxygen Therapy for the Treatment of Interstitial Cystitis: A Randomized, Sham Controlled, Double-Blind Trial J. Urology 2006, 176, 1442
Tissue hypoxia in complex regional pain syndrome Pain 2004, 104, 149
Bisphosphonates
    The bisphosphonates are a class of drugs usually prescribed to treat osteoporosis. Since long-term CRPS can cause loss of bone mass, in a process very similar to that of standard age-related osteoporosis, these drugs are commonly prescribed for older CRPS patients, many women, and any others for whom bone demineralization is more likely than usual, for a variety of reasons.
Bisphosphonates: Focus on Inflammation and Bone Loss Am. J. Therap. 2012, 19, 228
CRPS and Osteoporosis nice 12-pg pamphlet from the National Osteoporosis Society National Osteoporosis Society
Effect of Immunomodulating Medications in Complex Regional Pain Syndrome - A Systematic Review Clin. J. Pain 2012, 28, 355
Efficacy of Pamidronate in Complex Regional Pain Syndrome Type I Pain Med. 2004, 5, 276
An Open-label Pilot Trial of Ibandronate for Complex Regional Pain Syndrome Clin. J. Pain 2008, 24, 685
Role of Alendronate in Therapy for Posttraumatic Complex Regional Pain Syndrome Type I of the Lower Extremity Arth. & Rheum. 2004, 50, 3690
Role of Biphosphonates and Lymphatic Drainage Type Leduc in the Complex Regional Pain Syndrome (Shoulder–Hand Syndrome) Pain Med. 2009, 10, 179
The roles of the sympathetic nervous system in osteoporotic diseases: A review of experimental and clinical studies Aging Res. Rev. 2011, 10, 253
The successful use of pamidronate in an 11-year-old girl with complex regional pain syndrome: Response to treatment demonstrated by serial peripheral quantitative computerized tomographic scans Bone 2010, 46, 885
Treatment of Chronic Mechanical Spinal Pain with Intravenous Pamidronate: A Review of Medical Records J. Pain Sympt. Mngmt. 2003, 26, 678
Treatment of Reflex Sympathetic Dystrophy with Pamidronate: 29 cases Rheumatol. 2001, 40, 1394

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