Definitive Library for RSD/CRPS, Chronic Pain, and Similar Conditions
The RSD/CRPS Library
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Title of Article, Paper, Book, etc. (& link to PDF)
Citation
Drug Tolerance/Dependence/Addiction/Withdrawal
    Many of the drugs used in the treatment of CRPS/RSD, chronic pain, and related illnesses have the ability to cause tolerance and dependence - even addiction. Withdrawing from such drugs can be dangerous - even fatal - and it is very important that, if you're planning to discontinue a drug you've been taking for a long time, you do this with your physician's approval and guidance.
Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data Addiction 2003, 98, 1371
Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: Lessons from tramadol Biol. Psych. 2006, 73, 90
Abuse Liability of Alprazolam Relative to Other Commonly Used Benzodiazepines: A Review Neurosci. Biobehav. Rev. 1993, 17, 277
Addictive behaviors related to opioid use for chronic pain: A population-based study Pain 2013, 154, 2677
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human Brit. J. Pharmacol. 2011, 164, 1322
Antiepileptic Drug Withdrawal: Literature Review Mayo Clin. Proc. 2002, 77, 1378
Craving of Prescription Opioids in Patients With Chronic Pain: A Longitudinal Outcomes Trial J. Pain 2012, 13, 146
Dependence potential of antidepressants compared to benzodiazepines Prog. Neuropsychopharm. Biol. Psych. 2002, 26, 939
Does Report of Craving Opioid Medication Predict Aberrant Drug Behavior Among Chronic Pain Patients? Clin. J. Pain 2009, 25, 193
Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam Psychopharm. 2000, 150, 185
Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation Behav. Res. Ther. 2010, 48, 720
Focal nonconvulsive seizures during detoxification for benzodiazepine abuse Epilepsy & Behavior 2012, 23, 168
High dose benzodiazepine dependence: Description of 29 patients treated with flumazenil infusion and stabilized with clonazepam Psych. Res. 2012, 198, 457
Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence Pharmacol. Ther. 2012, 134, 219
Is There a Recreational Misuse Potential for Pregabalin? Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data Psychother. Psychosom. 2011, 80, 118
Long-term outcome after discontinuation of benzodiazepines for insomnia: a survival analysis of relapse Behav. Res. Ther. 2005, 43, 1
Managing Chronic Pain in Adults With or in Recovery From Substance Use Disorders (129pp) SAMHSA_Tip_No54
Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment Cephalagia 2012, 33, 52
Older Patient Perspectives on Long-Term Anxiolytic Benzodiazepine Use and Discontinuation: A Qualitative Study Soc. Gen. Int. Med. 2007, 22, 1094
Pain and Opioid Addiction: What is the Connection? Curr. Pain Headache Rep. 2010, 14, 17
Pregabalin for the discontinuation of long-term benzodiazepines use: An assessment of its effectiveness in daily clinical practice Euro. Psych. 2012, 27, 301
Pregabalin in the Treatment of Alcohol and Benzodiazepines Dependence CNS Neurosci. Ther. 2010, 16, 45
The safety and tolerability of zolpidem - an Update J. Psychopharmacol. 1999, 13, 81
Substance misuse treatment for high-risk chronic pain patients on opioid therapy: A randomized trial Pain 2010, 150, 390
Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse Addiction 2008, 103, 1572
Activated Glial Cells, Astrocytes, etc.
    The involvement of glial cells/structures, astrocytes, etc. in the maintenance and propagation of chronic neuropathic pain is a relatively new area of research. The articles marked by a gold star () are those which lay out the field in a general way at a level appropriate for an educated lay audience. Some of the cited articles are quite heavy; read them if you can, skip them otherwise.
Activated Glia: Targets for the Treatment of Neuropathic Pain Pract. Pain Mngmt. 2010 [Nov-Dec], 78
Activated Glia as Culprits in Opposing Opioid Analgesia & Driving Tolerance, Dependence & Reward Prof. Lana Watkins, Univ. of CO at Boulder
Activated Glia Induce Neuron Death Via MAP Kinase Signaling Pathways Involving JNK and p38 Glia 2004, 45, 170
Aging of Myelinating Glial Cells Predominantly Affects Lipid Metabolism and Immune Response Pathways Glia 2012, 60, 751
Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals Biochim. Biophys. Acta 2013, 1832, 650
Changes in immune and glial markers in the CSF of patients with CRPS Brain Behavior Immunity 2007, 21, 668
CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia PLoSOne 2013, 8, e57307
EFFECTS OF DISTAL NERVE INJURIES ON DORSAL-HORN NEURONS AND GLIA: RELATIONSHIPS BETWEEN LESION SIZE AND MECHANICAL HYPERALGESIA Neuroscience 2009, 158, 904
Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice Neurosci. Lett. 2011, 489, 43
Glia: a Novel Drug Discovery Target for Clinical Pain Natl. Review Drug Disc. 2003, 1
Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids Brain Behav. Immun. 2007, 21, 131
GLIA: A NOVEL DRUG DISCOVERY TARGET FOR CLINICAL PAIN (13 pp) Drug Disc. 2003, 2, 973
Glia: a Novel Drug Discovery Target for Clinical Pain (21pp) Natl. Review Drug Disc. 2003, 1
Glia: novel counter-regulators of opioid analgesia Trends Neurosci. 2005, 28, 661
Glial proteome changes in response to moderate hypothermia Proteomics 2012, 12, 2571
Glial TLR4 Receptor as New Target to Treat Neuropathic Pain: Efficacy of a New Receptor Antagonist in a Model of Peripheral Nerve Injury in Mice Glia 2008, 56, 1312
LIPOXIN A4 ANALOG ATTENUATES MORPHINE ANTINOCICEPTIVE TOLERANCE, WITHDRAWAL-INDUCED HYPERALGESIA, AND GLIALREACTION AND CYTOKINE EXPRESSION IN THE SPINAL CORD OF RAT Neurosci. 2012, 208, 1
The mechanisms of microgliosis and pain following peripheral nerve injury Exptl. Neurol. 2012, 234, 271
Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex J. Neurosci. 2013, 33, 4216
Microglial control of neuronal activity Frontiers Cell Neurosci. 2013, 7, 1
Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases J. Neuroinflamm. 2012, 9, 155
New Culprits in Chronic Pain Sci. Amer. 2009, 50
Pathological and protective roles of glia in chronic pain Nat. Rev. Neurosci. 2009, 10, 23
Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases Mol. Pain 2011, 7, 50
Resident glial cell activation in response to perispinal inflammation leads to acute changes in nociceptive sensitivity: Implications for the generation of neuropathic pain Pain 2013, 154, 71
Role of Astrocytes in Pain Neurochem. Res. 2012, 37, 2419
The role of kinin B1and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: Evidence for the involvement of astrocytes Neurobiol. Disease 2013, 54, 82
The role of non-synaptic extracellular glutamate Brain Res. Bull. 2013, 93, 17
Spinal astrocytes produce and secrete dynorphin neuropeptides Neuropeptides 2013, 47, 109
Spinal cord histopathological alterations in a patient with longstanding CRPS Brain Behavior Immunity 2009, 23, 85
The ‘‘Toll’’ of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia Trends Pharm. Sci. 2009, 30, 581
The Transcription Factor PU.1 is Critical for Viability and Function of Human Brain Microglia Glia 2013, 61, 929

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