Table of Contents
Articles/ Presentations/Classes PK-PD Analgesics Anticancer Benzodiazepines Molecular Modeling C&EN Articles

Technical Articles/Presentations/On-Line Classes
 

Anatomy - Medical Imaging

Virtual Autopsy excellent site, with 18 cases presented as would a pathologist's autopsy report. The cadaver is hyperlinked by system, providing the laboratory findings. The requested input is the deduced cause of death. There are several mini-tutorials on the body systems important to this kind of investigation.

Databases-Search Engines [many are found in the excellent listing from the ACS' Division of Medicinal Chemistry]

Title (hyperlinked to source)
Online?
Free?*
Description
y
y
database of measured binding affinities for biomolecules, genetically or chemically modified biomolecules, and synthetic compounds
y
y
highly rated clearinghouse for biomedical laboratories of any kind
y
y
super portal - search abstracts for over 500 journals, conferences, trade shows, online courses, books,
y
y
facilitates the analysis of Drug Binding Competitveness, with Computed Ligand-Receptor Interaction Energy; energy components; ligand classification, functions and properties. Ligand structure is also included
y
yfa
lists experimentally determined interactions between proteins, combining data from many sources to create a single, consistent set of protein interactions.
y
yfa
database of protein ligand and protein receptor pairs that are known to interact with each other.
y
y
Dedicated to the analysis of protein sequences and structures
y
y
two sections geared toward K-12 and advancved H.S. chemistry students
y
y
annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline SWISS-MODEL.
*y = yes without restrictions. yfa = yes, for academics


Pharmacokinetics-Pharmacodynamics Cytochrome c Oxidase - the "Molecule of the Month" entry from PBD's series.  Short tutorial on this oxidation catalyzing enzyme.


Background Reading on Major Drug Classes
Analgesics
PowerPoint slideshows
  • Adjuvant Analgesics   (32 slides) from Beth-Israel in New York - analgesics used in combination with others
  • Analgesics: Drug Discovery  (46 slides from Astra-Zeneca really excellent overview of NSAIDS, corticosteroids, and opiates, along with the mechanism of pain transmission
  • The Major Opioids   (52 slides) just what it says!  Nice summary, covering everything from pharmacology to business aspects.
  • Opioid Analgesics   (38 great slides from Beth-Israel) - really well done
  • Opioids in Chronic Pain  (36 slides from Beth-Israel) something near and dear to my foot....I mean, heart. ;-) A great slide show from one of the nation's experts on chronic pain and RSD
  • Etiology and Pathophysiology of Pain  (32 slides from Beth-Israel) nice explanation of the origin and transmission of pain signals - quite detailed, but not difficult to follow
  • Pathophysiology of Pain  (22 slides from Beth-Israel) concentrates on the physical reasons for and Tx of pain
  • Pharmacotherapy of Pain (63 slides from Beth-Israel) very complete outline of the Tx of pain
The Addict and the Law - essentially an early version of "Addiction and Opiates", this gives a fascinating look at the early days of drug prohibition and criminalization of drug addiction.
Addiction and Opiates - a critical review of the field by Alfred Lindesmith, one of the early authorities.
Consumers Union Report on Licit and Illicit Drugs- although somewhat dated (1972), it's still an excellent resource.
Definition of terms and classification of dependence-producing drugs
Discovery of Novel Opioid Medications   a multi-chapter NIDA report - 318pp!
Molecular Approaches to Drug Abuse Research   recommended chapters are marked in the table of contents
Neurological Processes of Pain  one of the
Talaria collection of tutorials, from the Pain Research Center at the Univ. of Utah - narrated, and it's actually not irritating!  Rather, it's the best example of narrated tutorials, and what they can accomplish, that I have ever encountered - CHECK THIS OUT!!
Opioid Receptors1   a good technical paper, surprisingly easy to read and follow
Opioids: Glossary1 not just opioid-related terms, but lots of pharmacological terms as well
Pharmacokinetics of the Opioids    combination outline/notes; primarily concerned with opioid use in terminal cancer
Use of Opioid Analgesics for the Treatment of Chronic Non-Cancer Pain  
a consensus report from the Canadian Pain Society, published in their journal, Pain Research & Management

c

AntiCancer Drugs

    
There are a multitude of sites with specific information about anticancer drugs, mechanisms of action, etc.  However, a great set of pages that encapsulates the data nicely is from Purdue's College of Vet. Medicine.  Hey, if the network is actually working, you'll be able to see the links from these pages to Purdue!

Chemotherapy   part of the Medical Pharmacology course
Pharmacology of Cancer Therapy   lengthy; essentially a set of lecture notes - very complete, outline form
Chemotherapy of Neoplastic Diseases   similar to above, except for more hard data are included
Table from above   outlines typical doses, routes, and precautions - very interesting, for the clinician
Table from above   covers drug preparations and storage - not as interesting as the above table, but worth a look Chemotherapy - Drug Groups  short tabulation - great overview

v

Benzodiazepines and Other Minor Tranquilizers

The Benzodiazepine Story  the whole story from Dr. Leo Sternbach, the discoverer of chlordiazepoxide (Librium®), the first benzodiazepine, along with diazepam (Valium®) and others, at Hoffmann-La Roche - great!
Benzodiazepines  (Systemic)
   from MedLinePlus, sponsored by NLM of the NIH - great, complete summary
Benzodiazepines for Anxiety  from a pamphlet from a U.K. health site
Stopping Long-Term Benzodiazepines  the joys of withdrawing from a very addictive class of drugs
About Benzodiazepines   from an Australian site about the dangers of long-term benzo therapy


Molecular Modeling/Imaging

  • 3D Pharmaceutical Structure Database  library of all Japanese Rx products, along with modeling software and tutorials.
  • Advanced Biomedical Computing Center  home of Sybyl, the comprehensive software package.
  • C4 Molecular Library   great way to get comfortable with Chime and to learn how to manipulate the >400 structures.
  • CAChe Computer Aided Chemistry  a well organized introduction to molecular modeling and how it is usp-ed.
  • Chime and Mozilla  Chime does not automatically install into browsers other than NS and IE, so here's how to use it with Mozilla.
  • Chime vs. Rasmol  although Chime is the modern and newer reincarnation of Rasmol.
  • Computers in Drug Design - Part 1 involves examining and appreciating the 3D aspects of the four potential anti-HIV agents with Chime; this outlines scripting with Chime, enabling the automated illustration of tutorials, primers, etc.  Part 2, on the other hand, enables you to manipulate the drug as it's bonded to the receptor.  Chime scripting allows it to run as a tutorial, where you click the buttons you're asked to; it a very effective way to visualize this complex interaction.

Current Items in Medicinal Chemistry from C&EN

  • Biotech Vies for Position  With the drug industry pressed to find new paths to innovation, the tension between large- and small-molecule therapeutics takes center stage.
  • Breaching Barriers  Protein transduction and similar methods are promising techniques for delivering a wide variety of drugs directly into cells.
  • Chiral Roundup   As pharmaceutical companies face bleak prospects, their suppliers diligently tend the fertile fields of chiral chemistry in varied ways.
  • Custom Synthesis for Drug Discovery  Companies provide exclusive synthesis for early drug development, keeping costs down until drug viability is assured.
  • Drug Development  Process chemistry results in pharmaceutical manufacturing routes that are safe, efficient, and scalable.
  • Drug Discovery  Pure science yields to applied science as the genomics revolution focuses its energy on commercialization.
  • Fighting the Clock  Pharmaceutical and biotechnology companies seek ways to reduce the time required to discover and develop medicines.
  • Fine Chemicals  A survey of fine chemical manufacturers and their tactics for dealing with a weak economy (other than working against Jr.'s re-election).
  • Generic Tide Is Rising  Expiring patent protections and pressures on makers of brand-name drugs bode well for the generic pharmaceutical industry.
  • Generics Next Wave  With major biotech drugs coming off patent, generic drug makers are looking to compete.
  • Green Chemistry for Pharma   Symposium highlights how chemists apply green chemistry principles to pharmaceutical problems.
  • Maximizing Returns   A driving force in getting Taxol to market quickly, NIH is being asked to evaluate the way it deals with the private-sector partnerships.  A great story about the development and marketing of Taxol®.
  • Pharmaceuticals, Supplied Virtually  Beta-Chem offers development capabilities despite owning neither plant nor lab.
  • Synthetic Receptors Pull Molecules Into Cells  custom targeting of synthetic receptors.

1. Both of these links are from the website opioids.com, which is a subdirectory of biopsychiatry.com; this site advocates and espouses a future utopian society, wherein everyone has a selection of psychoactive drugs to keep them in an "ecstatic" space, 24/7 (clearly, the site authors have been reading Aldous Huxley's "Brave New World").  Despite the site's rather unconventional premise, they are a source of a great many literature citations concerning just about any drug you could name.  I cannot support its main premise, but the site can be both educational and fun to peruse.  Where else could you find a homepage having the subtitle "The Responsible Parent's Guide to Healthy Mood-Boosters for All the Family"?


Got any links to add? Just drop me an e-mail with the link, and if it fits, it'll be in! Thanks!!

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