Table of Contents
Acid-Base Equilibria and Buffers lecture notes, graphics, examples, sample problems, etc. from a biochem lecture.
Study Questions not too long,
but you'll find it interesting, and may even learn something!
Pharmacology Tutorial adrenergic
SAR - uses Chime - nice.
Neurogenesis in Mammals a
short review article on an adult's ability to grow new
nerve cells - something thought impossible until very recently.
Membranes part of U.
Kansas' on-line book, Medical Biochemistry
Concepts in Biochemistry by Jim Hardy at U. Akron, who has authored a
number of great tutorials and on-line books
Drugs, Brains and
Behavior a full-length
electronic textbook by C. R. Timmons & L.W. Hamilton.
Drug Design from
the Molecular Design Laboratory in China.
Interactions a very readable chapter on the
forces between receptors and xenobiotics.
- Interactive Patient,
The very slick interactive diagnostic
drill - quite realistic, with both visual and audio feedback.
to Bacteria straightforward,
nine-page background item.
to PCR complete with a neat simulation of how this valuable
technique works to increase DNA quantities.
Biochemistry excellent, very complete text - not to be missed.
Medical Pharmacology and Disease-Based Integrated Instruction - basic pharmacology course for medical students.
Neurogenesis in Adult Mammals: Some Progress and Problems a followup piece to the fourth article down in this list.
Principles of Drug Action nice
PowerPoint presentation that hits all the essentials.
- Principles of Drug Action functional groups, acid-base chemistry and physicochemical properties. Includes study questions.
Protein G Structure Tutorial how to set up protein structures using Chime.
- Radiolabeling and Isotopic Markers Reading much like a short review article, "This website focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements."
Signal Transduction part of U. Kansas'
on-line book, Medical
Drug Design Review great J. Med. Chem. perspective on application of the 3D structures of protein target molecules in structure-based drug design.
Theory of Drug
Design a concise overview of the drug
discovery and development process. Several examples, developed
via their approach, are also presented. There are many other, quite sophisticated, pages on this site.
- Theory and Practice of Receptor Characterization and Drug Analysis actually a full, multiweek course.
Anatomy - Medical Imaging
Virtual Autopsy excellent site, with 18 cases presented as would a pathologist's autopsy report. The cadaver is hyperlinked by system, providing the laboratory findings. The requested input is the deduced cause of death. There are several mini-tutorials on the body systems important to this kind of investigation.
Databases-Search Engines [many are found in the excellent listing from the ACS' Division of Medicinal Chemistry]
Title (hyperlinked to source)
database of measured binding affinities for biomolecules, genetically or chemically modified biomolecules, and synthetic compounds
highly rated clearinghouse for biomedical laboratories of any kind
super portal - search abstracts for over 500 journals, conferences, trade shows, online courses, books,
facilitates the analysis of Drug Binding Competitiveness, with Computed Ligand-Receptor Interaction Energy; energy components; ligand classification, functions and properties. Ligand structure is also included
lists experimentally determined interactions between proteins, combining data from many sources to create a single, consistent set of protein interactions.
database of protein ligand and protein receptor pairs that are known to interact with each other.
Dedicated to the analysis of protein sequences and structures
two sections geared toward K-12 and advanced H.S. chemistry students
annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline SWISS-MODEL.
*y = yes without restrictions. yfa = yes, for academics
c Oxidase - the "Molecule of the Month"
entry from PBD's series. Short tutorial on this oxidation
- Dosage Forms from the FDA, a compilation of every drug formulation you've ever heard
of, and lots that you haven't.
- A First Course in Pharmacokinetics and Biopharmaceutics from the Univ. of Oklahoma College of Pharmacy.
- How the Kidney Works animated guide to kidney function - more sophisticated than it first appears.
- Interactive Clinical Pharmacology an elegant collection of 16 excellent, animated, *INTERACTIVE* tutorials that draw effective analogies between biological events and everyday occurrences. Representative titles include Drug Clearance, pH and Pharmacokinetics, Pharmacodynamics, and even Pharmacogenetics. Thus, an innate feel for a concept like homeostasis is acquired simply by analogy. Extremely ingenious!
- Principles of Drug Action and Therapeutics II brain chemistry, neurotransmitters, neurology
- Principles of Drug Action and Therapeutics III analgesics (opiates), local anesthetics, mental illness
- Pharmacokinetic Textbooks a well-researched and edited listing of the most widely used and highly regarded texts
- Pharmacokinetics an extremely nice summary of drug distribution, metabolism, receptor interaction - the big picture!
- Pharmacokinetics and Biopharmaceutics great course homepage from U. of IA, featuring excellent tutorials, lecture notes in either ppt or pdf format, sample questions, competencies, etc.
- Pharmacokinetics - Biopharmaceutics pharmaceutical analysis, molecular modeling, structure optimization. Some particularly good, fairly short chapters include the following:
- Routes of Drug Administration describes each route, with the
pluses/minuses for each.
- Pharmacokinetics of Oral Administration an introduction to the kinetics of oral drug delivery.
- Physical-Chemical Factors Affecting Oral Absorption discusses many factors, including the pH-partition hypothesis.
- Physiological Factors Affecting Oral Absorption membrane permeability, GI physiology (incl. pH).
- Distribution - discusses the "big picture" of drug distribution, esp. protein binding.
- Metabolism esp. renal, and its effect
on other body functions.
- Pharmacy - the WWW Virtual Library typical super collection of links from the Virtual Library - pharmaceutical schools, companies, databases, gov't. sites, conferences, etc.
- Routes of Administration very nice summary, by Cornell's Vet. Med. School.
- Your Kidneys and How They Work NIH's guide aimed at high school students...think it'll be beneath you? (It won't.)
Reading on Major
Analgesics (32 slides) from
Beth-Israel in New York - analgesics used in combination with others
- Analgesics: Drug Discovery (46 slides from Astra-Zeneca really excellent overview of NSAIDS, corticosteroids, and opiates, along with the mechanism of pain transmission
- The Major Opioids (52 slides) just what it says! Nice summary, covering everything from pharmacology to business aspects.
- Opioid Analgesics (38 great slides from Beth-Israel) - really well done
- Opioids in Chronic Pain (36 slides from Beth-Israel) something near and dear to my foot....I mean, heart. ;-) A great slide show from one of the nation's experts on chronic pain and RSD
and Pathophysiology of Pain (32 slides
from Beth-Israel) nice explanation of the origin and transmission of
pain signals - quite detailed, but not difficult to follow
of Pain (22 slides from Beth-Israel)
concentrates on the physical reasons for and Tx of pain
of Pain (63 slides from Beth-Israel) very
complete outline of the Tx of pain
Addict and the Law - essentially an early
version of "Addiction and Opiates", this gives a fascinating look at
the early days of drug prohibition and criminalization of drug
and Opiates - a critical review of the field by Alfred Lindesmith,
one of the early authorities.
Union Report on Licit and Illicit Drugs - although somewhat dated (1972),
it's still an excellent resource.
of terms and classification of dependence-producing drugs
Discovery of Novel Opioid Medications a multi-chapter NIDA report
Approaches to Drug Abuse Research recommended
chapters are marked in the table of contents
Neurological Processes of Pain one of the Talaria collection
of tutorials, from the Pain Research Center at
the Univ. of Utah - narrated, and it's actually not irritating!
the best example of narrated tutorials, and what they can accomplish,
have ever encountered - CHECK THIS OUT!!
Receptors1 a good technical paper, surprisingly easy to read
not just opioid-related terms, but
lots of pharmacological terms as well
Pharmacokinetics of the Opioids combination outline/notes; primarily
concerned with opioid use in terminal cancer
of Opioid Analgesics for the Treatment of Chronic Non-Cancer Pain
a consensus report from the Canadian Pain Society, published in their
Research & Management
There are a multitude of sites with
specific information about anticancer drugs, mechanisms of action,
etc. However, a great set of pages that encapsulates the data
nicely is from Purdue's College of Vet. Medicine. Hey, if the
network is actually working, you'll be able to see the links from these
pages to Purdue!
part of the Medical Pharmacology
a set of lecture notes - very complete, outline form
Neoplastic Diseases similar
to above, except for more hard data are included
Table from above outlines typical doses, routes, and precautions - very
interesting, for the clinician
from above covers drug
preparations and storage - not as interesting as the above table, but
worth a look Chemotherapy - Drug Groups
short tabulation - great overview
Benzodiazepines and Other Minor Tranquilizers
The Benzodiazepine Story the whole story from Dr. Leo Sternbach, the discoverer of chlordiazepoxide (Librium®), the first benzodiazepine, along with diazepam (Valium®) and others, at Hoffmann-La Roche - great!
Benzodiazepines (Systemic) from MedLinePlus, sponsored by NLM of the NIH - great, complete summary
Benzodiazepines for Anxiety from a pamphlet from a U.K. health site
Stopping Long-Term Benzodiazepines the joys of withdrawing from a very addictive class of drugs
About Benzodiazepines from an Australian site about the dangers of long-term benzo therapy
Molecular Modeling/Imaging (Also, check out my link library devoted to Modeling & Animation)
- 3D Pharmaceutical Structure Database library of all Japanese Rx products, along with
modeling software and tutorials.
- Advanced Biomedical Computing Center home of Sybyl, the comprehensive software package.
Molecular Library great way to get comfortable with Chime and to
learn how to manipulate the >400 structures.
- CAChe Computer Aided
Chemistry a well organized
introduction to molecular modeling and how it is used.
- Chime and Mozilla
Chime does not automatically install into browsers other than NS and
IE, so here's how to use it with Mozilla.
- Chime vs. Rasmol
although Chime is the modern and newer reincarnation of Rasmol.
in Drug Design - Part 1 involves
examining and appreciating the 3D aspects of the four potential
anti-HIV agents with Chime; this outlines
scripting with Chime, enabling the automated illustration of tutorials,
primers, etc. Part
2, on the other hand, enables you to manipulate the drug as it's
bonded to the receptor. Chime scripting allows it to run as a
tutorial, where you click the buttons you're asked to; it a very
effective way to visualize this complex interaction.
to Macromolecular Simulation a lengthy, mathematically rigorous
tutorial on classical vs. quantum mechanics.
to Molecular Modelling and Computer Simulation very good introduction to the whole
idea, plus loads of excellent links at the end of each section.
- An Introduction to QSAR Methodology great
starting point for QSAR novices - uses capsiacin
as a model substrate.
- Membrane Channel and Pump Structures a Chime
site covering the representation of channels. ion pumps, etc.; uses .
- Molecular Modeling
for Organic Chemistry an eight lecture/demo
course by Dr. Henry Rzepa (Imperial).
- Molecular Models over 1400 cmpds. in pdb
format, subdivided into categories like fnc. grp., type of application
Viewing Scripting Wizards an ingenious collection of
JS-powered aids to help write Chime and similar scripts.
- NSF, Science Magazine Honor Striking Visuals worth a look! Some of the most amazing images you'll see in
- The Online
Macromolecular Museum beautifully done display of
macromolecules from enzymes to proteins.
- ORTEP-III Oak Ridge Thermal Ellipsoid Plot Program for
Crystal Structure Illustrations.
Docking Using AutoDock 3.05 developed
by Prof. Arthur Olson at Scripps, this software is used for modeling
flexible small molecule such as drug molecule binding to receptor
- Quantitative Structure Activity
Relationships designed to
quantify the small differences between close analogs to give a more
accurate picture of the receptor, and hopefully to predict which
derivative(s) are likely to be most active.
- Rasmol Version 2.6-b-2 Reference Manual
best documentation of RasMol, the program largely replaced by Chime.
QSAR and Modeling Society an international organization supporting QSAR and
- The QSAR
Server capable of
online analysis using various methods and datasets.
- Sybyl/Base from Tripos® - " A Single Gateway to
Molecular Design and Analysis.
Current Items in Medicinal Chemistry from C&EN
1. Both of
these links are from the website opioids.com,
which is a subdirectory of biopsychiatry.com;
this site advocates and espouses a future utopian society, wherein
everyone has a selection of psychoactive drugs to keep them in an
"ecstatic" space, 24/7 (clearly, the site authors have been reading
Aldous Huxley's "Brave New World"). Despite the site's rather
unconventional premise, they are a source of a great many literature
citations concerning just about any drug you could name. I cannot
support its main premise, but the site can be both educational and fun
to peruse. Where else could you find a homepage having the
subtitle "The Responsible Parent's Guide to
Healthy Mood-Boosters for All the Family"?
Got any links to add? Just drop me an e-mail
with the link, and if it fits, it'll be in! Thanks!!